Week 16 NFL odds, picks, schedule, how to watch, streaming: Expert picks against the spread, best bets, more

It’s Week 16 in the NFL, which means it’s Fantasy championship time in a vast majority of leagues. What happens this weekend will decide who walks away with a Fantasy title, unless the matchup involves Alvin Kamara; those are likely over after the Saints star gashed the Vikings for six rushing touchdowns on Christmas. But for anyone still competing or for anyone with teams chasing a playoff spot in the actual league, there are some major matchups on the way this weekend, including the Colts facing the reeling Steelers, the Rams and Seahawks battling for the NFC West crown and the Titans trying to beat the NFC-leading Packers in Green Bay.

Each week, we’ll collect all of the best picks and gambling content from CBSSports.com and SportsLine in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. 

Enjoy our run-through of Week 16, and good luck in your games! All NFL odds via William Hill Sportsbook.

What picks can you make with confidence in Week 16? And which Super Bowl contender goes down hard? Visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, all from the model that is up over $7,800 on its top-rated picks.

Falcons at Chiefs

Time: Sunday, 1 p.m. ET (FOX), stream on fuboTV (Try for free) 

Latest Odds:

Kansas City Chiefs
-10.5

“Boy the Falcons can’t catch a break, can they? They blew a massive lead against Tom Brady (the jokes write themselves) and then roll right into a road matchup against Patrick Mahomes and the Chiefs. I don’t think Atlanta is going to put up much of a fight in this one, at least in terms of actually winning the game, but I do think the Chiefs have played too many close games to take them as a double digit favorite. They’re in cruise control for the No. 1 overall seed and I think Andy Reid will win without being too aggressive here.” — Will Brinson on why he has the Chiefs winning but the Falcons covering 

Brinson had the Saints as a best bet on Christmas and cashed that pretty easily, but you can see his best bets for every single Week 16 game in his Thursday column.

Giants at Ravens

Time: Sunday, 1 p.m. ET (FOX), stream on fuboTV (Try for free)  

Latest Odds:

Baltimore Ravens
-9.5

R.J. White: “I have a best bet on Under 45. Unders are 11-3 in Giants games this year, and I have no faith they’ll figure out the quarterback situation in this one. We’ll have a banged-up Daniel Jones trying to play, or Colt McCoy, who’s very limited. The Giants defense is great against the run; they’re sixth in yards per rush allowed. … That Giants offense scored seven against Arizona, six against Cleveland. I can’t expect better on the road in a tougher matchup here.” 

Kenny White: “You can add me to the best bet … I’m gonna go Under as well. With it being a must-win for both teams, and with both teams’ defenses better than their offenses, I made the total 37.5 … It’s definitely a best bet for me as well.” 

Will Brinson: “Let’s take the Under as the third leg of the parlay. I actually have Baltimore as a best bet at -11, because what they’re doing right now with their offense, and letting Lamar Jackson run, he’s cranked up his rushing the last four or five games and is starting to get loose.”

That’s from the Pick Six Podcast, where I join Pete Prisco, Kenny White and Will Brinson every Friday to break down all the games from a gambling perspective, give out best bets and put together a Pick Six Parlay, which has hit four times this season. Give it a listen below and subscribe for great NFL content in your feed daily.

Bengals at Texans

Time: Sunday, 1 p.m. ET (FOX), stream on fuboTV (Try for free)  

Latest Odds:

Houston Texans
-7

“This is a terrible spot for the Bengals, who are coming off a 110 percent effort game against the hated Steelers where they secured an improbable win. Now they have a quick turnaround to play a meaningless game during the holiday week. I can’t see them showing up at all here, while Deshaun Watson seems likely to carve up a Cincinnati defense that ranks 25th in net yards per pass attempt, especially as the Bengals defense has just 16 sacks on the year. The Bengals scraped together just 78 yards of pass offense in the win last week, marking six straight games under the 210 mark since their bye. Don’t expect them to keep up with Watson in this one.” — R.J. White on why the Texans are one of his best bets for Week 16

I’ve cashed twice in the Las Vegas SuperContest, widely considered the toughest sports gambling competition in the world. I’ve also hit on over 57% of my picks over the past five years combined. You can see all five of my Week 16 NFL picks against the SuperContest lines by heading to SportsLine, and use promo code WHITE to sign up for $1 for your first month of access to all SportsLine’s picks and analysis. 

Browns at Jets

Time: Sunday, 1 p.m. ET (CBS), stream on CBS All Access  

Latest Odds:

Cleveland Browns
-7

“The Browns are in the division race with the Steelers faltering, but they need to be careful here. The Jets played well last week in beating the Rams on the road. Cleveland is back in the same stadium after playing there Monday night against the Giants. They handled the Giants with ease, but this will be a little tougher. The Jets will hang around.” — Pete Prisco on why he likes the Jets to cover 

Prisco made the Jets a best bet on the Pick Six Podcast, where he’s nailed 59.5% of his best bets on the season. You can see all his final score predictions for Week 16 in his Wednesday column.

Colts at Steelers

Time: Sunday, 1 p.m. ET (CBS), stream on CBS All Access 

Latest Odds:

Indianapolis Colts
+1.5

“I don’t think the Steelers are going to win another game. There’s something wrong with Ben Roethlisberger, and this entire offense. Philip Rivers continues to play mistake-free football. Lay the small number.” — Hammerin’ Hank Goldberg on why the Colts are one of his best bets 

A Vegas legend, Goldberg is on a blistering 45-27 run on his best bets going back to last season. You can see all three of his best bets for Week 16 over at SportsLine.

Bears at Jaguars

Time: Sunday, 1 p.m. ET (CBS), stream on CBS All Access

Latest Odds:

Chicago Bears
-8

“The Jaguars are in great position to hold onto the No. 1 overall pick in the 2021 NFL Draft, they just have to continue to lose. With their victory on Sunday, the 1-13 New York Jets are no longer the sole possessors of the worst record in the NFL. Not only that, but the Jaguars have an easier strength of schedule, which puts them in the driver’s seat for the No. 1 overall pick. The Bears, on the other hand, have won back-to-back games since their long six-game losing streak. They’ve scored 30-plus points in all three games since Mitchell Trubisky returned as the starter, and really have been rolling as of late. Don’t overthink this pick.” — Jordan Dajani on why the Bears are one of his best bets 

While Dajani has struggled with his best bets on the season, his overall ATS record is well above .500, so you’ll want to check out his entire slate of Week 16 picks in his Thursday column.

Broncos at Chargers

Time: Sunday, 4:05 p.m. ET (CBS), stream on CBS All Access    

Latest Odds:

Los Angeles Chargers
-3

“Do I believe in the Chargers? No. Do I believe less in Drew Lock? Yes. Lock had his one good December game already against Carolina. Denver topped the Chargers earlier this year, but that was back when they had no clue how to win close games. You’ll recall L.A. went into the fourth quarter up 24-10 and ended the game with Lock dancing on them. Justin Herbert for Offensive Rookie of the Year.” — Jonathan Jones on why he thinks the Chargers win this week 

Jones has racked up an impressive 150-72-1 record on straight-up picks after a 12-4 performance in Week 15. You can see all his picks for Week 16 in his Friday column.

Panthers at Washington

Time: Sunday, 4:05 p.m. ET (CBS), stream on CBS All Access 

Latest Odds:

Washington Football Team
-1

“Honestly, I just love betting on Teddy Bridgewater as an underdog. He’s rewarded me plenty of times before. As a starter, Bridgewater’s teams are a ridiculous 24-6 ATS as an underdog. This season the Panthers have gone 7-3 ATS as dogs with Bridgewater, and that 7-3 record is his worst single-season performance. To take this a step further, when he’s a road dog, Bridgewater’s teams are 19-2. Nineteen. And. Two. That includes six straight covers this season against teams like the Saints, Chiefs, and Packers, just to name a few. Washington’s been playing better in recent weeks, but they’re nowhere near as good as those teams. If Teddy can cover against them, he can cover against Washington.” — Tom Fornelli on why the Panthers are one of his best bets for Week 16 

Fornelli put together another .500 week but is looking to finish the season strong with a pair of 3-0 weeks. You can see the three picks he loves in his Thursday column.

Rams at Seahawks

Time: Sunday, 4:25 p.m. ET (FOX), stream on fuboTV (Try for free) 

Latest Odds:

Seattle Seahawks
-1

“Los Angeles was able to beat the Seahawks back in Week 10, 23-16. The Rams gave Russell Wilson fits throughout that contest, picking him off twice and sacking him three times. That performance wasn’t just a one-off as the Rams have largely dominated Seattle under Sean McVay. They are 5-2 SU against the Seahawks under McVay and are currently 3-0 ATS since the start of last season. L.A. also owns a +58 point differential in those games under McVay. More recently, Seattle is 3-7 ATS coming into Week 16 since starting 4-0 ATS. The Rams are 4-0 ATS following their last 4 ATS losses, which is noteworthy after being upset by the Jets in Week 15.” — Tyler Sullivan on why the Rams are one of his locks 

Sully is coming off a .500 week and hovering around .500 overall on the season, but you can find his five locks for Week 16 in his Wednesday column.

Eagles at Cowboys

Time: Sunday, 4:25 p.m. ET (FOX), stream on fuboTV (Try for free) 

Latest Odds:

Philadelphia Eagles
-3

“The one thing I will say about the Cowboys is that they were my preseason pick to win the division and I’ve decided to ride that train until it crashes, which means I have to pick them to win here. To be honest, I’m kind of hoping the train crashes this week. I mean, I don’t think I realized how much anxiety being on the Cowboys bandwagon can cause you. Jalen Hurts has been playing out of his mind, but if I’ve noticed one thing about rookie quarterbacks, it’s that they eventually come back down to earth after a hot start, and nothing would be a bigger rookie reality check than losing to your biggest rival.” — John Breech on why he’s taking the Cowboys to win outright in this matchup

Breech is coming off a down ATS week, but if you think he’s due for a rebound, you can see the rest of his picks in his Tuesday column, and be sure to sign up for the Pick Six newsletter to get more Breech in your inbox all week long.   

Titans at Packers

Time: Sunday, 8:20 p.m. ET (NBC), stream on fuboTV (Try for free)    

Latest Odds:

Green Bay Packers
-3

I’m putting together a massive run over at SportsLine, entering Week 16 on a 50-31-5 (+1505) streak with my ATS picks that includes a 15-3 record over the last three weeks. That’s on top of a 67-43-5 (+1890) record on my last 115 picks overall, including the Saints covering on Christmas. 

But I’ve been even better picking Packers games over the years, putting together a 40-11 record on my last 51 against-the-spread picks involving the Packers. I’m leaning toward the Over, but I have a stronger play on the spread in Titans vs. Packers, which you can find over at SportsLine.

Bills at Patriots

Time: Monday, 8:15 p.m. ET (ESPN), stream on fuboTV (Try for free)    

Latest Odds:

Buffalo Bills
-7

Mike Tierney is a national sportswriter whose work appears in The New York Times and Los Angeles Times, but he also entered the 2020 season as the No. 1 NFL expert on SportsLine, where he put together a 66-44 ATS record in 2019 and a 63-46 ATS record in 2018 as part of a 282-222 mark over the previous four years. 

Tierney has delivered a strong record in Bills games as well, hitting on 10 of his last 14 against the spread picks involving Buffalo. He’s leaning Under on the total, but if you want to see which side of the Bills vs. Patriots spread he likes, you can find it over at SportsLine.

Thanks for checking us out, and good luck with your picks!