Clemson vs. Ohio State odds, line: College Football Playoff picks, predictions from model on 56-36 run

The Clemson Tigers have made each of the last six College Football Playoffs and the Ohio State Buckeyes have been eliminated by the Tigers in each of their last two trips to the playoffs. On New Year’s Day, the programs will clash in the College Football Playoff semifinals for the second year in a row in the 2021 Sugar Bowl at the Mercedes-Benz Superdome in New Orleans. Clemson won 29-23 last year to end Ohio State’s season before losing to LSU in the national title game.

The game is scheduled for 8 p.m. ET on Friday. The No. 2 Tigers (10-1) are favored by 7.5 points against the No. 3 Buckeyes (6-0) in the latest Clemson vs. Ohio State odds from William Hill Sportsbook and the over-under is listed at 67. Before entering any Ohio State vs. Clemson picks, you’ll want to see the college football predictions and betting advice from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It enters the final week of bowl season a sizzling 56-36 on all top-rated picks, returning over $400. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Ohio State. You can head to SportsLine to see its picks. Here are several college football odds for Ohio State vs. Clemson:

  • Clemson vs. Ohio State spread: Clemson -7.5
  • Clemson vs. Ohio State over-under: 67 points
  • Clemson vs. Ohio State money line: Clemson -290, Ohio State +230
  • CLEM: The Tigers have won and covered in each of their three CFP matchups with the Buckeyes.
  • OSU: The Buckeyes are 6-1 against the spread in their last seven games on a Friday.

Latest Odds:

Clemson Tigers
-7.5

Why Clemson can cover

The Tigers have been to four of the last five CFP championship games and Dabo Swinney’s program continues to challenge Alabama as the most dominant in the country in the last 10 years. Quarterback Trevor Lawrence is a Heisman Trophy finalist for the first time in his already storied career after throwing for 2,753 yards and 22 touchdowns with just four interceptions while rushing for seven more scores.

Lawrence put up 412 yards of total offense and three total touchdowns in the ACC Championship Game win over Notre Dame and lit Ohio State up for 366 total yards and three total touchdowns in the CFP semis last season. However, Lawrence is far from a one-man show, as Travis Etienne has put up 1,406 scrimmage yards and scored 15 times while Amari Rodgers has caught 69 passes for 966 yards and seven touchdowns. Stopping that trio will be a tall order with Etienne and Rodgers both putting up over 120 scrimmage yards and scoring against a tough Notre Dame defense.

Why Ohio State can cover

The Buckeyes averaged a whopping 7.3 yards per play in 2020 and took to the ground to swat away an early scare from Northwestern in the Big Ten title game. Ohio State finished that contest with 399 yards on the ground and average 9.1 yards per carry with Trey Sermon rushing for 331 yards and two scores in the victory.

It was a career day for the Oklahoma transfer and with Clemson likely focusing its defensive efforts on slowing down Justin Fields, Sermon’s ability to create big plays in the running game could shift the balance. The Buckeyes averaged 42.5 points and 529.2 yards per game this season and had a plus-eight turnover differential in just six games. Stealing a couple possessions against the favored Tigers could help the Buckeyes stick around.

How to make Clemson vs. Ohio State picks

The model has simulated Ohio State vs. Clemson 10,000 times and the results are in. It is leaning under on the total, and it’s also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Clemson vs. Ohio State? And which side of the spread is hitting in almost 60 percent of simulations? Visit SportsLine right now to see which side of the Ohio State vs. Clemson spread you need to jump on, all from the computer model that has crushed its college football picks, and find out.